Glycolysis and Oxidative Phosphorylation in Neurons and Astrocytes during Network Activity in Hippocampal Slices

What is it about?

Network activation triggers a significant energy metabolism increase in both neurons and astrocytes. Using simultaneous measurements of electrophysiological and metabolic parameters during synaptic stimulation in hippocampal slices, we showed that neurons and astrocytes use both glycolysis and oxidative phosphorylation to meet their energy demands. Our data did not support the hypothesis of a preferential utilization of astrocyte-released lactate by neurons during network activation (so- called lactate shuttle hypothesis) --instead, we showed that during such activity glucose is an effective energy substrate for both neurons and astrocytes.

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