What is it about?
Exploring the in vitro influence that cAMP and cGMP have on the maintenance of latency or signaling for reactivation of herpes simplex type-1 virus infecting neuroblastoma cells.
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Why is it important?
Better understanding the regulation of HSV-1 latency in host neural cells is essential for the pathogenic, the clinical course, and the therapeutic strategies developed to modify the viral infection and its consequences.
Perspectives
Developing and working on this in-vitro model of herpes infection of neural cells was a challenge at some time, but once the induction of viral latency and its reactivation by adding or removing different second intracellular messengers like cAMP and cGMP was achieved, studying their influence on herpes simplex infectivity status became very exciting.
Dr. Alejandro Rodriguez-Garcia
Instituto Tecnologico y de Estudios Superiores de Monterrey
Read the Original
This page is a summary of: The role of cyclic nucleotide mediators in latency and reactivation of HSV-1 infected neuroblastoma cells, Eye, September 1991, Springer Science + Business Media,
DOI: 10.1038/eye.1991.109.
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