Computational Modeling to Accelerate the Identification of Substrates and Inhibitors for Transporters That Affect Drug Disposition

  • S Ekins, J E Polli, P W Swaan, S H Wright
  • Clinical Pharmacology & Therapeutics, September 2012, Springer Science + Business Media
  • DOI: 10.1038/clpt.2012.164

using computational models for transporters

What is it about?

Describes in simple terms how computational approaches are important for drug transporter research.

Why is it important?

This brought together opinions of multiple key drug transporter researchers that have implemented computational methods to assist in finding inhibitors or substrates. It describes various pros and cons of computational approaches.

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http://dx.doi.org/10.1038/clpt.2012.164

The following have contributed to this page: Dr Sean Ekins