What is it about?
Homeostasis of dNTP pools is vital for cell viability, thus, a valuable tool in research is quantification intracellular dNTP levels. Here, we provide a non-radioactive technique that enables determination of dNTPs using a polymerase-based assay and click chemistry.
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Why is it important?
This technique replaces radioisotope-labeling and avoids handling of biohazard materials.
Perspectives
I hope this article provides a safer technique for research in dNTP metabolism.
Miriam Yagüe Capilla
Karolinska Institutet
Read the Original
This page is a summary of: Quantitation of deoxynucleoside triphosphates by click reactions, Scientific Reports, January 2020, Springer Science + Business Media,
DOI: 10.1038/s41598-020-57463-3.
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