What is it about?
Cancer associated fibroblasts modify tumor microenvironment (via MCP-1 and SDF-1 cytokines) in a way that suppresses immune system.
Photo by Todd Cravens on Unsplash
Why is it important?
Cancer associated fibroblasts (CAFs) seem to play pivotal roles in sculpturing the tumour microenvironment in breast cancer, and therapeutic strategies to reverse the CAF-mediated immunosuppressive microenvironment should be taken into consideration.
Read the Original
This page is a summary of: Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs, Scientific Reports, February 2019, Springer Science + Business Media, DOI: 10.1038/s41598-019-39553-z.
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