What is it about?

Cancer associated fibroblasts modify tumor microenvironment (via MCP-1 and SDF-1 cytokines) in a way that suppresses immune system.

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Why is it important?

Cancer associated fibroblasts (CAFs) seem to play pivotal roles in sculpturing the tumour microenvironment in breast cancer, and therapeutic strategies to reverse the CAF-mediated immunosuppressive microenvironment should be taken into consideration.

Perspectives

In this study, we examined the relationship between cancer-associated fibroblasts (CAFs) and monocytes/macrophages in breast cancer. Our findings show that activated tumour stroma may have explicit functions in terms of macrophage polarization. We suggest that CAFs may recruit monocytes and induce these recruited monocytes to differentiate into PD-1 expressing M2-like macrophages, instead of M1 macrophages. Recruitment of monocytes by CAFs might be mediated by MCP-1 and SDF-1 cytokines.

Gurcan Gunaydin
Hacettepe University Cancer Institute

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This page is a summary of: Cancer associated fibroblasts sculpt tumour microenvironment by recruiting monocytes and inducing immunosuppressive PD-1+ TAMs, Scientific Reports, February 2019, Springer Science + Business Media, DOI: 10.1038/s41598-019-39553-z.
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