Effective gamma-ray sterilization and characterization of conductive polypyrrole biomaterials

Semin Kim, Jin-Oh Jeong, Sanghun Lee, Jong-Seok Park, Hui-Jeong Gwon, Sung In Jeong, John George Hardy, Youn-Mook Lim, Jae Young Lee
  • Scientific Reports, February 2018, Nature Publishing Group
  • DOI: 10.1038/s41598-018-22066-6

Effective sterilization and characterization of conductive polypyrrole biomaterials

What is it about?

Topic: Sterilisation of conductive polymer-based biomaterials. Detail: Conductive polymers, including polypyrrole (PPy), have been extensively explored to fabricate electrically conductive biomaterials for bioelectrodes and tissue engineering scaffolds. For their in vivo uses, a sterilization method without severe impairment of original material properties and performance is necessary. Gamma-ray radiation has been commonly applied for sterilization of medical products because of its simple and uniform sterilization without heat generation. Herein we describe the first study on gamma-ray sterilization of PPy bioelectrodes and its effects on their characteristics. We irradiated PPy bioelectrodes with different doses (0–75 kGy) of gamma-rays. Gamma-ray irradiation of the PPy (γ-PPy) increased the oxygenation and hydrophilicity of the surfaces. Interestingly, gamma-ray irradiation did not alter the electrical impedances and conductivities of the PPy substrates. Additionally, γ-PPy prepared with various dopants (e.g., para-toluene sulfonate, polystyrene sulfonate, and chlorine) showed the electrochemical properties similar to the non-irradiated control. Gamma-ray irradiation at doses of ≥15 kGy was required for effective sterilization as evidenced by complete eradication of gram positive and negative bacteria. γ-PPy substrates also showed cytocompatibility similar to untreated control PPy, indicating no substantial alteration of cytocompatibility. In conclusion, gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.

Why is it important?

Gamma ray sterilization is a viable method of sterilization of conducting polymer-based biomaterials for biomedical applications.

Perspectives

Dr John George Hardy (Author)
Lancaster University

My first collaborative research publication with Prof. Jae-Young Lee from the prestigious Gwangju institute of science and technology.

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http://dx.doi.org/10.1038/s41598-018-22066-6

The following have contributed to this page: Dr John George Hardy