Catch the tiger by the tail: a strategy to target viral proteins that change constantly?

What is it about?

To maximize host cell subversion, viruses often produce proteins lacking defined structure, otherwise known as disordered proteins. These proteins are like 'viral multi-tools', allowing viruses to appear in many different ways and attack many targets inside cells at once. These proteins are also challenging therapeutic targets since medicines typically need a structurally fixed binding site. In this report, we discuss how Hendra virus V protein binds human transporter proteins and adopts a fixed structure, potentially revealing a new therapeutic target. 宿主細胞の混乱を最大化するために、ウイルスはよく非構成化タンパク質を生産します。しかし、医薬は一般的にタンパク質の固定構造を結合するから、これらのタンパク質は治療目標として難しいです。本稿では、ヘンドラウイルス「V」タンパク質が固定構造を採用し、新しい治療標的を明らかにする方法について説明したい。

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Photo by Dean Nahum on Unsplash

Photo by Dean Nahum on Unsplash