Antibiotic treatment for Tuberculosis induces a profound dysbiosis of the microbiome that persists long after therapy is completed

  • Matthew F. Wipperman, Daniel W. Fitzgerald, Marc Antoine Jean Juste, Ying Taur, Sivaranjani Namasivayam, Alan Sher, James M. Bean, Vanni Bucci, Michael S. Glickman
  • Scientific Reports, September 2017, Springer Science + Business Media
  • DOI: 10.1038/s41598-017-10346-6

What is it about?

Antibiotics for Tuberculosis alter the gut microbiome both during treatment (which lasts for 6 months, at least), and for more than 1 year after treatment is completed.

Why is it important?

This alteration, called dysbiosis, may explain some interesting epidemiological observations in the TB field, for example, why people who are cured of TB are more than 4x more likely to become re-infected with a new strain.

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The following have contributed to this page: Dr Matthew F Wipperman