What is it about?
Ergodicity breaking on the neuronal surface.
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Why is it important?
Stochastic motion on the surface of living cells is critical to promote molecular encounters that are necessary for multiple cellular processes. We unravel two manifestations of ergodicity breaking in the dynamics of membrane proteins in the somatic surface of hippocampal neurons.
Perspectives
We have exploited and probed ergodicity on a trajectory-by-trajectory basis. It was found that most of the trajectories in the soma surface are non-ergodic. However, when we investigate the non-confined parts of the trajectories, ergodicity is recovered, pinpointing the mechanism behind ergodicity breaking. This behaviour, found for three vastly different membrane proteins emphasizes the neuronal surface complexity, where a classical simple fluid description fails at multiple scales.
Aleksander Weron
Politechnika Wroclawska
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This page is a summary of: Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states, Scientific Reports, July 2017, Springer Science + Business Media,
DOI: 10.1038/s41598-017-05911-y.
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