What is it about?

We find hot spots on the plasma membrane, at least partially defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins are confined and preferentially couple.

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Why is it important?

These findings shed new light on the dynamic interactions that control G-protein-coupled receptor signalling.

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This page is a summary of: Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots, Nature, October 2017, Springer Science + Business Media,
DOI: 10.1038/nature24264.
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