Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease

  • I Celardo, A C Costa, S Lehmann, C Jones, N Wood, N E Mencacci, G R Mallucci, S H Y Loh, L M Martins
  • Cell Death and Disease, June 2016, Nature Publishing Group
  • DOI: 10.1038/cddis.2016.173

Mitochondrial dysfunction triggers ER stress in Parkinson's models

What is it about?

Some inherited forms of early-onset Parkinson’s disease have typically been blamed on poorly functioning mitochondria, the powerhouses of cells. Without reliable sources of energy, neurons wither and die. This may not be the complete picture of what is happening within cells affected by Parkinson’s. We found that the bulk of the damage to neurons stems from a related but different source - the neighbouring maze-like endoplasmic reticulum (ER).

Perspectives

Dr L. Miguel Martins
MRC Toxicology Unit

Interesting to find-out that defective mitochondria "talk" to the endoplasmic reticulum.

Read Publication

http://dx.doi.org/10.1038/cddis.2016.173

The following have contributed to this page: Dr L. Miguel Martins and Dr Susann Lehmann