What is it about?
Osteoprotegerin plays a role in the development of several bone diseases. In addition, it may contribute to the development of vascular disease. We examined the association between serum osteoprotegerin levels and both the presence and severity of lower extremity arterial disease expressed by toe-brachial index measurement in patients with type 2 diabetes.
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Why is it important?
In the present study we used toe-brachial index to define peripheral arterial disease severity. Although the patients with severe medial arterial calcification (ankle-brachial index≥1.3) were excluded from the present study, we used toe-brachial index<0.7 for the diagnosis of peripheral arterial disease, because of its sensitivity to detect peripheral arterial disease also in patients who have peripheral arterial disease with normal values of ankle-brachial index as a result of the masking effect of the moderate degree medial arterial calcification.
Perspectives
Our data showed that increased serum osteoprotegerin levels were associated with both the presence and severity of peripheral arterial disease in patients with type 2 diabetes independently from traditional risk factors. Although the exact pathophysiologic effect of osteoprotegerin on the lower extremity arterial stenosis is unknown, our findings indicate that serum osteoprotegerin might be a biomarker for the presence of atherosclerotic disease. Despite the limitations, our study contributes to the current understanding of the multiple functions of osteoprotegerin in diabetes and atherosclerosis.
Katarina Demkova
Univerzita Pavla Jozefa Stafarika v Kosiciach
Read the Original
This page is a summary of: Osteoprotegerin concentration is associated with the presence and severity of peripheral arterial disease in type 2 diabetes mellitus, VASA, March 2018, Hogrefe Publishing Group,
DOI: 10.1024/0301-1526/a000682.
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