What is it about?
Hyperuricemia is recognized as a lifestyle-related disease and the prevalence is increasing in many parts of the world. Dietary fiber has a suppressive effect for various lifestyle-related diseases, such as the dyslipidemia, diabetes, obesity, and hypertension, to some extent. We have shown that dietary fiber has a suppressive effect on serum uric acid concentration in experimental hyperuricemic rats (overproduction-type and underexcretion-type). This article explains the suppressive effect of dietary fiber on the different types of dietary hyperuricemia and the mechanisms concerned regarding aspects of digestion and absorption of dietary purines.
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Why is it important?
Recent clinical research has demonstrated that increased dietary fiber intake decreased serum uric acid concentrations and is associated with lower hyperuricemia risk. The basic research results of our series concerning the suppressive effect of dietary fiber on hyperuricemia stimulated subsequent clinical research into this matter. We wish to emphasize the importance of recognizing the validity of increased dietary fiber intake as a preventive or suppressive method for hyperuricemia and its comorbidities, such as chronic kidney disease, obesity, and hypertension.
Perspectives
Writing this article in International Journal for Vitamin and Nutrition Research was a great pleasure. Hyperuricemia often coexists with other important diseases, such as chronic kidney disease, cardiovascular disease, hypertension, diabetes. Many epidemiological studies have shown that increased dietary fiber intake is associated with decreased risk of comorbidity of hyperuricemia. We hope that the association between dietary fiber consumption and serum uric acid levels in hyperuricemia patients with or without comorbidities will be further elucidated in large-scale prospective cohort studies and randomized controlled trials in the future.
Takashi Koguchi
Kokugakuin Daigaku
Read the Original
This page is a summary of: Beneficial Effect of Dietary Fiber on Hyperuricemia in Rats and Humans: A Review, International Journal for Vitamin and Nutrition Research, July 2019, Hogrefe Publishing Group,
DOI: 10.1024/0300-9831/a000548.
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