What is it about?

Chronic hyperglycemia status favors the manifestation of oxidative stress by increasing the production of reactive oxygen species and/or by reducing the antioxidant defense system activity. In this study, the beneficial effects of apple cider vinegar (ACV) supplementation on blood glucose level, hepatic and renal toxicity and antioxidant enzyme activities in normal and diabetic rats were investigated.ACV was administrated orally for 4 weeks. Our findings indicated that ACV increased the activity of antioxidant enzymes (superoxide dismutase, catalase and glutathione peroxidase) as well as thiol concentration. It also reduced lipid peroxidation levels and the indices of toxicity in liver and kidneys, by significantly decreasing aspartate and lactate transaminase activity, total and direct bilirubin , urea and creatinine levels. Moreover, the plasma concentration of magnesium, calcium and copper increased after ACV administration. Iron levels however decreased. The concentration of vitamin E, an important antioxidant in vivo, was raised. In conclusion, the findings show that ACV possesses significant antihyperglycemic and antioxidant effects in an experimental model of DM, by preventing diabetic complications in liver and kidneys.

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Why is it important?

Apple cider vinegar prevente diabetic complications in liver and kidneys


more extensive pharmacological experiments are required.

Halima Ben Hmad
Universite de Tunis El Manar

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This page is a summary of: Antidiabetic and Antioxidant Effects of Apple Cider Vinegar on Normal and Streptozotocin-Induced Diabetic Rats, International Journal for Vitamin and Nutrition Research, December 2018, Hogrefe Publishing Group, DOI: 10.1024/0300-9831/a000246.
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