What is it about?
We carried out a dual synthetic strategy, providing new access to monotrans EPA isomers and valuable information on GC and NMR characteristics for further applications in metabolomics and lipidomics. This small library was used as an analytical reference for isomer determination in deodorized fish oils and the follow-up of rats fed fish oil diets.
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Why is it important?
Evidencing for the first time that mono-trans EPA isomers are incorporated in liver mitochondrial membranes after dietary intake.
Perspectives
The natural cis double bond geometry can be transformed to the trans configuration during the deodorization process utilized in the food industry. The analytical discrimination of the possible five mono-trans regioisomers represents a limiting step for the recognition and structure–activity relationship in connection with the harmful effects of trans fatty acids in health.
Dr Stanislav A Grabovskiy
Ufa Institute of Chemistry of the RAS
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This page is a summary of: Trans Fatty Acids: Chemical Synthesis of Eicosapentaenoic Acid Isomers and Detection in Rats Fed a Deodorized Fish Oil Diet, Chemical Research in Toxicology, March 2012, American Chemical Society (ACS),
DOI: 10.1021/tx200467c.
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