NTCP pharmacophore and bayesian models
What is it about?
The sodium taurocholate cotransporting polypeptide (NTCP) is a key bile acid transporter. We describe using a set of compounds to develop a pharmacophore which is used to identify additional FDA approved drugs as inhibitors. A bigger dataset is created and used to build a Bayesian model. This inturn is tested with additional drugs. We compared ASBT and NTCP activity and suggested the former is more permissive.
Why is it important?
A combination of computational and in vitro approaches was used to discover new NTCP inhibitors across many different therapeutic classes. This study showed that small datasets can be used to enlarge the number of inhibitors discovered.
The following have contributed to this page: Dr Sean Ekins