hOCTN2 substrate pharmacophore
What is it about?
Initially a common features pharmacophore was generated with 9 substrates for the hOCTN2 transporter. The pharmacophore was used to identify other known substrates and search drug databases. The pharmacophore seemed to identify compounds with known incidence of rhabdomyolysis.
Why is it important?
This was the first substrate pharmacophore for this transporter developed. This work also suggested a link between hOCTN2 and rhabdomyolysis.
The following have contributed to this page: Dr Sean Ekins