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Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiations. In addition, a one-pot process from 4H-pyrido[1,3]oxazin-4-one precursors (imide sodium salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in their global synthetic preparation. This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of application.

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This page is a summary of: Access to Pyridyl-Substituted 1,3,5-Triazines from 4 H -Pyrido[1,3]oxazin-4-ones via a Cyclocondensation Process , The Journal of Organic Chemistry, July 2014, American Chemical Society (ACS), DOI: 10.1021/jo5010668.
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