Access to Pyridyl-Substituted 1,3,5-Triazines from 4 H -Pyrido[1,3]oxazin-4-ones via a Cyclocondensation Process

Laetitia Le Falher, Omar Ben Ayad, Ozge Ziyaret, Alexander Mamontov, Candice Botuha, Serge Thorimbert, Franck Slowinski
  • The Journal of Organic Chemistry, July 2014, American Chemical Society (ACS)
  • DOI: 10.1021/jo5010668

What is it about?

Pyridyl-substituted 1,3,5-triazines were synthesized in good to excellent yields via an unprecedented one-step cyclocondensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiations. In addition, a one-pot process from 4H-pyrido[1,3]oxazin-4-one precursors (imide sodium salts) was developed and led to the desired triazines compounds, thus allowing a one-step economy in their global synthetic preparation. This approach provides rapid access to pyridyl (or pyridone)-substituted 1,3,5-triazines with high potential in various fields of application.

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The following have contributed to this page: Professor Serge THORIMBERT