Synthesis of Phenanthrone Derivatives from sec- Alkyl Aryl Ketones and Aryl Halides via a Palladium-Catalyzed Dual C−H Bond Activation and Enolate Cyclization

Parthasarathy Gandeepan, Kanniyappan Parthasarathy, Chien-Hong Cheng
  • Journal of the American Chemical Society, June 2010, American Chemical Society (ACS)
  • DOI: 10.1021/ja1026248

Phenanthrone Synthesis

What is it about?

This article describes a direct synthesis of phenanthrone derivatives and ortho arylated ketones via C-H bond activation.

Why is it important?

A detailed mechanistic study were performed. The reaction mechanism was proved by isolation of organo palladium intermediate. The reaction follow multiple C-H bond activation and enolate cyclization.

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http://dx.doi.org/10.1021/ja1026248

The following have contributed to this page: Gandeepan Parthasarathy