Ln(IV) and An(IV) complexes with 3,4,3-LI(1,2-HOPO) ligand

What is it about?

This work is focused on the solution thermodynamics of complexes formed between lanthanide(IV) or actinide(IV) ions and the decorporation agent 3,4,3-LI(1,2-HOPO). A new strategy was developed in order to determine experimentally the formation constants of the Ce(IV)/HOPO and Th(IV)/HOPO complexes. The complexes were found extraordinarily stable in aqueous solutions (log Beta> 40) and corroborate the observed excellent efficacy of 3,4,3-LI(1,2-HOPO) as an in vivo actinide decorporation agent

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Why is it important?

Formation constants of Ce(IV)-3,4,3-LI(1,2-HOPO) and Th(IV)-3,4,3-LI(1,2-HOPO) complexes were determined for the first time. This allows predictions on the stability of the corresponding U(IV), Np(IV) and Pu(IV) complexes. Comparisons with the reference ligand (DTPA) provide a thermodynamic basis for the observed higher efficacy of 3,4,3-LI(1,2-HOPO) as an in vivo actinide decorporation agent.