What is it about?
MMP-2 regulatory pathway is initiated in alveolar macrophages during acute lung injury (ALI), which may increase pulmonary inflammation. Therefore, there is a critical need for fast and reliable techniques to track the acute respiratory distress syndrome (ARDS). Here, we describe near-infrared fluorescence resonance energy transfer (NI-FRET) MMP-2-based probe for the in vivo detection of ALI induced by lipopolysaccharides (LPS).
Featured Image
Why is it important?
LPS-induced MMP-2 was measured using near-infrared (NIR) imaging after 1, 2, 4, 5, and 24 h of LPS exposure. Our results were compared with the data obtained from ELISA and Western blotting, demonstrating that MMP-2 fluorescence probe provide a promising in vivo diagnostic tool for ALI/ARDS in infected mice.
Perspectives
Hopefully, this scientific paper highlights (NIR-FRET) imaging to detect ARDS in order to provide a significant contribution to health care diagnosis
Dr. Nuha Khalid Alekhmimi
Inaya Medical College
Read the Original
This page is a summary of: In Vivo Near-Infrared Fluorescence Resonance Energy Transfer (NIR-FRET) Imaging of MMP-2 in ALI/ARDS in LPS-Treated Mice, ACS Omega, January 2024, American Chemical Society (ACS),
DOI: 10.1021/acsomega.3c07614.
You can read the full text:
Contributors
The following have contributed to this page
