What is it about?

We previously found that this "isoxazole" drug could improve the function of insulin-producing cells in the pancreas (the beta cells). In this paper, we analyzed the effects of isoxazole in greater depth.

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Why is it important?

We found that isoxazole can slow down the replication rate of the insulin-producing cells, which might be part of the way this drug improves the function of the cells. We also found that injecting diabetic mice with this drug might offer some protection from high blood glucose. This suggests that in the future, more powerful versions of this isoxazole drug could be created that work even better.

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This page is a summary of: Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells, ACS Chemical Biology, April 2016, American Chemical Society (ACS),
DOI: 10.1021/acschembio.5b00993.
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