De Novo Engineering of Solid-State Metalloproteins Using Recombinant Coiled-Coil Silk

Trevor D. Rapson, Tara D. Sutherland, Jeffrey S. Church, Holly E. Trueman, Helen Dacres, Stephen C. Trowell
  • ACS Biomaterials Science & Engineering, November 2015, American Chemical Society (ACS)
  • DOI: 10.1021/acsbiomaterials.5b00239

Designing new proteins for industrial biotech applications

What is it about?

We use a silk protein from honeybees to make materials which mimic naturally occurring proteins such as hemoglobin in our blood.

Why is it important?

This work in a paradigm shifting approach to developing new protein materials suitable for applications such as sensors and biocatalysts.


Trevor Rapson

This is undoubtedly my favorite paper. What I love about these materials is they are so robust. You can leave them on you lab bench for months or soak them in harsh organic solvents and they survive. They are also incredibly simple to produce - see the videos as an example of this. I look forward to seeing what real world applications we can apply these solid-state metalloproteins to.

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