What is it about?
the monohydroxy-DMC and monohydroxy-BDMC showed better protective activities than did the curcumin, DMC, and BDMC in hydrogen peroxide-induced cell deaths in HaCaT cells.
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Why is it important?
Commercial preparations of curcumin generally contain 77% curcumin, 17%−18% DMC, and 5%−6% BDMC. Low amounts of curcumin analogs are found in nature, such as monohydroxy- DMC [1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)- 1,6-heptadiene-3,5-dione], monohydroxy-BDMC [1-(3,4-dihydroxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene- 3,5-dione], and tetrahydroxycurcumin, which are also referred to as members of the curcuminoids.
Perspectives
Hydrogen peroxide was used to mimic the UV-induced apoptosis of the HaCaT keratinocyte through the elevation of ROS levels. Pretreatments with the minor components of curcuminoids, monohydroxy-DMC and monohydroxy-BDMC, were shown to recover the cell viability and reduce apoptotic cell populations through the reduction of intracellular ROS levels via attenuating GPx activity and HO-1 protein expression and suppressing p53, c-Fos, and c-Jun protein and/or gene expressions. The potential of monohydroxy-DMC and monohydroxy-BDMC as ingredients in future antioxidant, antiradical, or antiaging cosmetics for skin care warrants further investigation.
Professor Wen-Chi Hou
Taipei Medical University
Read the Original
This page is a summary of: Protective Effects of Minor Components of Curcuminoids on Hydrogen Peroxide-Treated Human HaCaT Keratinocytes, Journal of Agricultural and Food Chemistry, May 2016, American Chemical Society (ACS),
DOI: 10.1021/acs.jafc.6b01196.
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