Vitisin A exhibited anti-obesity activities in high-fat diet-induced mice models

What is it about?

In this study, extracts, fractions and purified compounds from VTT were intervened concurrently with high-fat diets (HF). The C57BL/6J mice were fed with HF concurrently with ethanol extracts (Et-ext) from roots (R), stems (S) and leaves (L) by oral gavage daily to investigate the possibilities of anti-obesity activity by VTT extracts. Furthermore, the Et-ext from VTT-R were fractionated into ethyl acetate-partitioned fraction (EA-fra), n-butanol-partitioned fraction (BuOH-fra) and water fraction (water-fra), and also used for the anti-obesity experiments. Three resveratrol tetramers were purified from EA-fra of R-Et-ext and used for the anti-obesity experiments, while fenofibrate was used for comparisons.

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Why is it important?

The intervened R-Et-ext at a dose of 80 mg/kg, but not S-Et-ext and L-Et-ext, showed reduced mice weight gains compared to those fed HF only (the control) from day 19 to day 33, and showed significant difference (* P < 0.05; ** P < 0.01; *** P < 0.001) during the feeding experiments. The present data also showed that S-Et-ext, L-Et-ext and R-Et-ext at 80 mg/kg could improve obesity-related cardiovascular risk parameters, such as total cholesterols (TC), total triglycerides (TG) and low-density lipoproteins (LDL).

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