What is it about?
The fall armyworm (FAW) is a serious agricultural pest and has developed resistance to multiple insecticides. It is necessary to introduce novel insecticide(s) for controlling FAW. Isocycloseram is a completely novel isoxazoline insecticide. However, its activity and mode of action against FAW have not been reported. In this study, isocycloseram exhibited a higher insecticidal activity (LC50 = 0.26 mg/kg) than fipronil (LC50 = 7.72 mg/kg) against FAW. The median inhibitory concentration (IC50) of isocycloseram (IC50 = 8.52 nM) was almost equal to that of the desmethyl-broflanilide (IC50 = 7.32 nM) to the SfrRDL1 receptor. The IC50 of isocycloseram to the SfrRDL2 receptor was 11.13 nM, which was obviously less than that of desmethyl-broflanilide, dieldrin, fipronil, fluxametamide. Compared with the SfrRDL2 receptor, the SfrRDL1 receptor exhibited higher sensitivity to GABAergic insecticides. The recombinant SfrGluCl receptor was successfully stimulated by L-glutamate; however, the currents were low and weakly inhibited by isocycloseram at 10 μM.
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Why is it important?
Our results provided the theoretical basis for usage of GABAergic insecticides for controlling FAW.
Perspectives
Isocycloseram has high insecticidal activity to FAW as well as broflanilide, desmethyl-broflanilide, fluxame-tamide, and cyproflanilide, but obviously better than fipronil. Our results firstly provide electrophysiological evidence for isocycloseram significantly inhibiting the SfrRDL and SfrGluCl receptors. Therefore, isocycloseram is a promising new insecticide with great potential for effectively controlling FAW in the field.
Ph.D Tao Tang
Institute of Plant Protection, Hunan Academy of Agricultural Sciences
Read the Original
This page is a summary of: Comparative Insecticidal Activity and Mechanism of Isocycloseram versus Other GABAergic Insecticides against the Fall Armyworm, Journal of Agricultural and Food Chemistry, August 2024, American Chemical Society (ACS),
DOI: 10.1021/acs.jafc.4c02866.
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