What is it about?

We show that ppGpp binds directly to the transcription factor XdhR, which in turn leads to increased expression of genes encoding xanthine dehydrogenase. Xanthine dehydrogenase is important for recycling of purines, which is important for synthesis of ppGpp during starvation.

Featured Image

Why is it important?

During starvation, de novo synthesis of purines is reduced. This work shows that a positive feedback loop exists in which ppGpp leads to increased salvage of purines, which is required for ppGpp synthesis.

Read the Original

This page is a summary of: The Stringent Response Induced by Phosphate Limitation Promotes Purine Salvage in Agrobacterium fabrum, Biochemistry, October 2017, American Chemical Society (ACS),
DOI: 10.1021/acs.biochem.7b00844.
You can read the full text:

Read

Contributors

The following have contributed to this page