Pyrazolo[3,4- d ]pyrimidinophanes: Convenient Synthesis of a New Class of Cyclophane and X-ray Structure of the First Representative †

Kamlakar Avasthi, Amantullah Ansari, Ashish K. Tewari, Ruchir Kant, Prakas R. Maulik
  • Organic Letters, November 2009, American Chemical Society (ACS)
  • DOI: 10.1021/ol902264t

What is it about?

Simple synthesis of cyclic compounds from easily accessible pre-organised acyclic starting material.

Why is it important?

Gives first entry into novel class of Pyrazolo[3,4-d]pyrimidinophanes: Closely related to purinophanes based on purine constituent of DNA.

Perspectives

kamlakar avasthi (Author)
Central Drug Research Institute

High yield of cyclophane is direct consequence of pre-organised shape of starting material in solution without resorting to high dilution and syringe pump technique.

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