Vibrational Coupling between Helices Influences the Amide I Infrared Absorption of Proteins: Application to Bacteriorhodopsin and Rhodopsin

Eeva-Liisa Karjalainen, Andreas Barth
  • The Journal of Physical Chemistry B, April 2012, American Chemical Society (ACS)
  • DOI: 10.1021/jp300329k

What is it about?

Calculations of the protein infrared absorption of helix bundles revealed that the spectrum is influenced by coupling of C=O (amide I) vibrations in different helices. This shows that the amide I band is influenced not only by secondary structure but also by tertiary structure.

Why is it important?

This work provides a long sought explaination for the unusually high amid I frequency of bacteriorhodopsin trimers.

The following have contributed to this page: Professor Andreas Barth