What is it about?
Our cells have an interesting enzyme, called p300/CBP. Its function seems simple enough: to append a small chemical modification onto target proteins to regulate their activities. However, studying its activity in the test tube and inside cells has revealed layers of complex, dynamic interactions that govern this enzyme, and moreover we have come to appreciate its significance in a variety of diseases including cancer, heart disease, diabetes, obesity, and HIV. Astonishingly, this research has not yet translated into a cure, and we make some recommendations to help galvanize this effort.
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Why is it important?
This chapter is a resource for researchers interested in p300/CBP. It explains, evaluates, and puts into context a wealth of experimental results and technologies, from landmark historical discoveries to exciting new developments. It is the most thorough review of all the known acetyltransferase inhibitor drugs, and also of all the known potential medical applications of those targeting p300/CBP.
Read the Original
This page is a summary of: Protein Lysine Acetylation by p300/CBP, Chemical Reviews, January 2015, American Chemical Society (ACS), DOI: 10.1021/cr500452k.
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