What is it about?

a straightforward and rapid synthesis of(±)-tapentadol was achieved, with better diastereoselectivity,from totally different and commercially relevant raw materials.

Featured Image

Why is it important?

The synthetic operation from cheaply available tetrahydrothiopyr-an-4-one provided an added advantage of scale up at a lower cost than the acyclic strategy.


higher diastereoselectivity was obtained as compared with previous routes

Dr. Kranthi Kumar Ramagonolla
Harvard University

Read the Original

This page is a summary of: Tetrahydrothiopyran-4-one as Five-Carbon Source for Scalable Synthesis of (±)-Tapentadol, Organic Process Research & Development, June 2019, American Chemical Society (ACS), DOI: 10.1021/acs.oprd.9b00121.
You can read the full text:



The following have contributed to this page