What is it about?
3,3′-Diindolylmethane (DIM), a digestive metabolite originating from cruciferous vegetables. Although intestinal permeability dysfunction is closely related to the cause of intestinal inflammatory diseases (IBDs), the effect of DIM on intestinal permeability is unclear. In this paper, DIM improves intestinal permeability dysfunction in a model animal, Caenorhabditis elegans and cultured human intestinal cells.
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Why is it important?
Here, we reported an experimental system to evaluate the intestinal permeability by using human intestinal cell layers and the model nematode Caenorhabditis elegans. This method will be convenient for basic biological scientists who study the interaction between the gut microbiota and gut health, as well as investigators who develop probiotics and nutraceuticals for the prevention and treatment of intestinal health problems, such as leaky gut syndrome and inflammatory bowel diseases.
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This page is a summary of: 3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans, Journal of Agricultural and Food Chemistry, July 2019, American Chemical Society (ACS), DOI: 10.1021/acs.jafc.9b03039.
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