What is it about?
3,3′-Diindolylmethane (DIM), a digestive metabolite originating from cruciferous vegetables. Although intestinal permeability dysfunction is closely related to the cause of intestinal inflammatory diseases (IBDs), the effect of DIM on intestinal permeability is unclear. In this paper, DIM improves intestinal permeability dysfunction in a model animal, Caenorhabditis elegans and cultured human intestinal cells.
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Why is it important?
Here, we reported an experimental system to evaluate the intestinal permeability by using human intestinal cell layers and the model nematode Caenorhabditis elegans. This method will be convenient for basic biological scientists who study the interaction between the gut microbiota and gut health, as well as investigators who develop probiotics and nutraceuticals for the prevention and treatment of intestinal health problems, such as leaky gut syndrome and inflammatory bowel diseases.
Perspectives
DIM is a digestive metabolite of cruciferous vegetables including broccoli, cabbage, and kale. This chemical can also improve intestinal permeability dysfuction of a model animal, C. elegans. It's good for worms as well as humans.
Dr. Kyungsu Kang
Korea Institute of Science and Technology
Read the Original
This page is a summary of: 3,3′-Diindolylmethane Improves Intestinal Permeability Dysfunction in Cultured Human Intestinal Cells and the Model Animal Caenorhabditis elegans, Journal of Agricultural and Food Chemistry, July 2019, American Chemical Society (ACS),
DOI: 10.1021/acs.jafc.9b03039.
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