What is it about?
In this article, we talk about five new ternary and one double multicomponent crystals of ciprofloxacin with salicylic acid. In addition, we found two polymorphs: [CIP+SA+H2O] (1:1:1) Form I and [CIP+SA+H2O] (1:1:1) Form II, one of which is displaying “disappearing polymorph” behavior. However, we managed to obtain a vanishing polymorph using method mechanochemistry and DVS experiments.
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Why is it important?
This is important because endangered polymorphs are a headache for both scientists and the pharmaceutical industry.
Read the Original
This page is a summary of: Solid Forms of Ciprofloxacin Salicylate: Polymorphism, Formation Pathways, and Thermodynamic Stability, Crystal Growth & Design, March 2019, American Chemical Society (ACS), DOI: 10.1021/acs.cgd.9b00185.
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