What is it about?
A combination of relatively rigid macrocycle of the studied calixarenes and their long flexible substituents capable of H-bonding gives almost infinite number of polymorphs depending on the preparation procedure. The hydrophilicity of one of these calixarenes can be switched on/off by consecutive treatment with different organic solvent vapors and drying, which gives hydrophilic or hydrophobic polymorph.
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Why is it important?
The results give insight into the structural factors of polymorphophism, which can be extrapolated to pharmaceuticals.
Read the Original
This page is a summary of: Smart Polymorphism of Thiacalixarene with Long-Chain Amide Containing Substituents, Crystal Growth & Design, May 2017, American Chemical Society (ACS), DOI: 10.1021/acs.cgd.7b00463.
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