Redox-Sensitive MarR Homologue BifR from Burkholderia thailandensis Regulates Biofilm Formation

Ashish Gupta, Stanley M. Fuentes, Anne Grove
  • Biochemistry, April 2017, American Chemical Society (ACS)
  • DOI: 10.1021/acs.biochem.7b00103

A transcription factor that represses genes involved in biofilm formation

What is it about?

When the gene encoding the transcription factor BifR is inactivated, cells form more biofilm. Among the genes under control of BifR is an operon that encodes proteins responsible for synthesizing alternate electron acceptors. Such alternate electron acceptors promote biofilm formation, as cells embedded in the biofilm experience lower levels of oxygen, which is the preferred electron acceptor.

Why is it important?

Cells in a biofilm are more resistant to antibiotics. Understanding events that promote biofilm formation may lead to mechanisms by which they may be disrupted, thus enhancing efficacy of conventional antibiotics.

The following have contributed to this page: Prof. Anne Grove