What is it about?

Calcium is an important signaling molecule in the brain. It has been challenging to measure calcium activity at the subcellular level. Researchers developed a new tool which measures subcellular calcium activity in brain cells called astrocytes.

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Why is it important?

This tool will enable researchers to study highly localized calcium activity in the brain cells which have tremendous applications in understanding how neurodegenerative diseases and substance use affects brain activity.


It was great pleasure to work on this project. My advisor and collaborators were very supportive. Their continuous encouragement helped to develop this tool and finally bring it out in the form of a publication. We are also thinking about other ways to make this tool accessible for research community around the world.

Surya P Aryal
University of Kentucky

Read the Original

This page is a summary of: ER-GCaMP6f: An Endoplasmic Reticulum-Targeted Genetic Probe to Measure Calcium Activity in Astrocytic Processes, Analytical Chemistry, January 2022, American Chemical Society (ACS),
DOI: 10.1021/acs.analchem.1c04321.
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