Elevated plasma norepinephrine inhibits insulin secretion, but adrenergic blockade reveals enhanced β-cell responsiveness in an ovine model of placental insufficiency at 0.7 of gestation

“

IUGR has been associated with developmental adaptations in insulin secretion and insulin action that have lasting consequence to metabolic health. In this work we show that islets are susceptible to programming actions even before fetal growth declines. These findings indicate that insulin secretion from the beta cells is modified by adrenergic stimulation, which demonstrates endocrine regulation in the fetal programming of islets.

”