TDOA-based microwave imaging algorithm for real-time microwave ablation monitoring

What is it about?

Microwave ablation is widely recognized as a promising minimally invasive tool for treating cancer. Real-time monitoring of the dimensions of the ablation zone is indispensable for ensuring an effective and safe treatment. In this paper, we propose a microwave imaging algorithm for monitoring the evolution of the ablation zone. Our proposed algorithm determines the boundary of the ablation zone by exploiting the time difference of arrival (TDOA) between signals received before and during the ablation at external antennas surrounding the tissue, using the interstitial ablation antenna as the transmitter.

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Why is it important?

A significant advantage of this method is that it requires few assumptions about the dielectric properties of the propagation media. Also the simplicity of the signal processing, wherein the TDOA is determined from a cross-correlation calculation, allows real-time monitoring and provides robust performance in the presence of noise. We investigate the performance of this approach for the application of breast tumor ablation.