Postoperative Iridium-192 brachytherapy for Keloid treatment

What is it about?

For developing countries like Pakistan where the per capita income is very low, the patient convenience and cost effectiveness of any treatment without compromising the control rate is a question of major concern. he purpose of this study was two-fold; first to report our experience with a HDR iridium-192 surface mould brachytherapy of keloid scars after surgical excision, using different radiation treatment regimen and second to establish the most convenient and cost effective treatment protocol, having no compromise on the treatment outcomes. The results of this study show that a dose regimen of 10 Gy (BED=20 Gy) in a single fraction have comparable results with a dose regimen of 15 Gy in three fractions or 18 Gy in three fractions. Dose regimen of 10 Gy in a single fraction is therefore, considered to be the most convenient and cost effective dose regimen for the management of keloid scars in developing countries like Pakistan. Dose scheme of 8Gy in a single fraction is considered suboptimal and discouraged in practice.

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Why is it important?

There have been many studies with postoperative HDR iridium- 192 brachytherapy published by various researchers. But to the best of our knowledge there is no study ever been published on the comparison of single versus multiple fractions iridium-192 surface mould HDR brachytherapy regarding postoperative keloid treatment