What is it about?
The purinergic receptor P2X7 (P2X7R) is involved in both normal neural signaling and pathogenesis of a variety of neuroinflammatory and neurodegenerative diseases. In this paper, the contribution of P2X7Rs to physiological retinal (ERG) responses was studied under a variety of stimulation conditions. The early pathological effects produced by the overstimulation of the P2X7Rs are also demonstrated.
Featured Image
Why is it important?
The results are the first to show the effects of the endogenous ATP through its P2X7 receptors on the ERG responses in lower vertebrates. The dependence of the P2X7R-mediated effects on stimulus intensity, photoreceptor input and state of adaptation is demonstrated. This is the first study in which the effects on the ERG ON and OFF responses are separately demonstrated and compared. The earliest pathological ERG changes produced by the overstimulation of the P2X7Rs are shown and discussed.
Perspectives
It has been shown how the endogenous ATP through its P2X7 receptors operates in different stimulation conditions. Its effects on the ERG are characterized over the whole dynamic range in both dark- and light-adapted retinae. Rod-mediated, cone-mediated and mixed rod and cone-mediated responses are isolated and compared. An ON/OFF response asymmetry of the P2X7R-mediated effects is also demonstrated. A mechanism of autocrine action of ATP on photoreceptor P2X7Rs is indirectly supported. The earliest pathological effects of the P2X7R overstimulation are demonstrated and discussed.
Petia Kupenova
Medical University of Sofia
Read the Original
This page is a summary of: Purinergic modulation of frog electroretinographic responses: The role of the ionotropic receptor P2X7, Visual Neuroscience, January 2017, Cambridge University Press,
DOI: 10.1017/s0952523817000128.
You can read the full text:
Contributors
The following have contributed to this page
