What is it about?
Gastro-duodenal ulcer is associated with gastric Helicobacter pylori. Antibiotics are recommended to "eradicate" the bacterium. Our results: the bacterium eradication is not definitive, but transient: more than a third of children, after an apparently complete cure of H. pylori colonisation, have a relapse within 10 years. This could partly explain why antibiotic therapy for H. pylori does not reduce gastric cancer incidence. Susceptible patients should be followed to treat any relapse.
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Why is it important?
Eradication, i.e. definitive clearance of H. pylori colonisation, is usually the objective of antibiotic therapy. This is clearly not the case: relapse is frequent (more than a third of children after initial cure relapse within 10 years. There is also a marching cohort effect: immigrants are 4 times more susceptible to get H. pylori colonisation than Belgian children.
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This page is a summary of: Follow-up ofHelicobacter pyloriinfection in children over two decades (1988–2007): persistence, relapse and acquisition rates, Epidemiology and Infection, June 2013, Cambridge University Press,
DOI: 10.1017/s0950268813001428.
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