Most of the genetic covariation between major depressive and alcohol use disorders is explained by trait measures of negative emotionality and behavioral control

What is it about?

Alcohol use and major depressive disorder co-occur at a relatively high rate, but it is unclear why this happens. We found that over half of their co-occurrence is due to common genetic factors. Most of this genetic influence was related to a tendency to experience negative emotions and lack impulse control .

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Why is it important?

These findings suggest that treatments targeting stress sensitivity or impulse control may be helpful for addressing a wide range of problems.