What is it about?
The sheep tapeworm Moniezia expansa is very common parasite, which affects ruminants. Anthelmintics albendazole (ABZ), flubendazole (FLU) and mebendazole (MBZ) are often used to treat the infection. Reduction of MBZ, FLU and oxidation of ABZ were proved. The sheep tapeworm is able to deactivate administered anthelmintics, and thus protects itself against their action.
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Why is it important?
Our findings show that the tapeworms are able to deactivate anthelmintic drugs, and thus protect themselves against their action.
Read the Original
This page is a summary of: Biotransformation of anthelmintics and the activity of drug-metabolizing enzymes in the tapeworm Moniezia expansa, Parasitology, November 2014, Cambridge University Press,
DOI: 10.1017/s0031182014001711.
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