What is it about?
The aim of the present study was to evaluate genetic differences between adults of the Belo Horizonte (BH) strain of S. mansoni able to successfully infect mice with distinct immunological backgrounds, and to determine whether specific S. mansoni DNA markers are associated with different host immune backgrounds.
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Why is it important?
In summary, we have demonstrated that RAPD-PCR is a useful tool for assessing genetic differences between experimental populations of S. mansoni and could lead to the discovery of specific host interaction markers. The molecular mechanisms involved in host–parasite interaction are complex and imply bilateral cross-talk, with signals in both directions giving rise to distinct genetic variants.
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This page is a summary of: The role of the immunological background of mice in the genetic variability of Schistosoma mansoni as detected by random amplification of polymorphic DNA, Journal of Helminthology, July 2014, Cambridge University Press,
DOI: 10.1017/s0022149x14000492.
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