What is it about?
In this manuscript, we report the first evidence that consumption of fermentable non-digestible oligosaccharides commonly elevated colonic alkaline phosphatase (ALP) activity by up-regulating the expression of IAP-I as well as improved gut barrier function, fermentation, and microflora in rats fed a high-fat diet.
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Why is it important?
Our findings suggest that the elevated effects of non-digestible oligosaccharides on colonic ALP may be important for protection of gut epithelial homeostasis.
Perspectives
Small intestinal ALP has an established protective effect against inflammatory, and several nutrients such as vitamin D and K have been reported to enhance small intestinal ALP. On the other hand, little information exists on whether colonic ALP activity and the expression of ALP gene is affected by dietary condition, and whether non-digestible carbohydrates affect gut ALP. The present results suggest that the elevated effects of non-digestible oligosaccharides on colonic ALP may be important for protection of gut epithelial homeostasis.
Yukako Okazaki
Read the Original
This page is a summary of: Consumption of non-digestible oligosaccharides elevates colonic alkaline phosphatase activity by up-regulating the expression of IAP-I, with increased mucins and microbial fermentation in rats fed a high-fat diet, British Journal Of Nutrition, November 2018, Cambridge University Press,
DOI: 10.1017/s0007114518003082.
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