What is it about?
Poor maternal nutrition predisposes offspring to metabolic disease. This predisposition is modified by various postnatal factors.
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Why is it important?
We hypothesised that coupled to the initial effects of developmental programming due to a maternal low-protein diet, a second hit resulting from increased offspring postnatal sugar consumption would lead to additional changes in metabolism and adipose tissue function.
Perspectives
The present study shows that a second hit during adulthood can amplify the effects of higher adiposity arising due to poor maternal pregnancy diet in an offspring sex dependent fashion.
Jorge Rodríguez-Antolín
Universidad Autonoma de Tlaxcala
Read the Original
This page is a summary of: Sugared water consumption by adult offspring of mothers fed a protein-restricted diet during pregnancy results in increased offspring adiposity: the second hit effect, British Journal Of Nutrition, October 2013, Cambridge University Press,
DOI: 10.1017/s0007114513003000.
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