What is it about?
We elucidated the molecular changes involved in one of the pathways (Tp53) at an early stage of colon cancer in rats exposed to diets containing the non-digestible fraction of cooked bean.
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Why is it important?
These changes were mediated by signalling pathways involved in apoptosis, cell-cycle regulation and arrest, inhibition of proliferation and inflammation and DNA repair.
Perspectives
Common bean fiber (non-digestible fraction) exerts chemoprotective effects on early stage of colon cancer.
Dr B. Dave Oomah
Formerly with AAFC
Read the Original
This page is a summary of: Non-digestible fraction of beans (Phaseolus vulgaris L.) modulates signalling pathway genes at an early stage of colon cancer in Sprague–Dawley rats, British Journal Of Nutrition, August 2012, Cambridge University Press,
DOI: 10.1017/s0007114512000785.
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