Gamma-hydroxybutyrate (GHB), an unusual cause of high anion gap metabolic acidosis

Laurence Carlier, Vincent Van Belleghem, Kathleen Croes, Frederik Hooft, Matthias Desmet, Olivier Heylen, Stijn Lambrecht, Stefaan Carlier
  • CJEM, May 2017, Cambridge University Press
  • DOI: 10.1017/cem.2017.10

GHB and high-anion-gap-metabolic-acidosis

What is it about?

The causes of high anion gap metabolic acidosis (HAGMA) are well described in the literature. However, sometimes more frequent causes of HAGMA cannot explain its occurrence. In the case of HAGMA and severe neurological depression in the absence of other causes of HAGMA, clinicians should consider an intoxication with gamma-hydroxybutyrate (GHB) as a possible cause.

Why is it important?

The causes of high anion gap metabolic acidosis (HAGMA) are well described in the literature. However, sometimes more frequent causes of HAGMA cannot explain its occurrence.

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http://dx.doi.org/10.1017/cem.2017.10

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