Associations of trauma exposure and post-traumatic stress disorder with the activity of the renin–angiotensin–aldosterone-system in the general population

Jan Terock, Anke Hannemann, Deborah Janowitz, Harald J. Freyberger, Stephan B. Felix, Marcus Dörr, Matthias Nauck, Henry Völzke, Hans J. Grabe
  • Psychological Medicine, June 2018, Cambridge University Press
  • DOI: 10.1017/s0033291718001496

Trauma and PTSD are associated with increased renin activity

What is it about?

Exposure to traumatic Events ist associated with increased renin Levels. In subjects also suffering from PTSD, renin Levels are even higher. After correction for the number of Traumas, PTSD was still associated with increased renin Levels compared to subjects without PTSD

Why is it important?

It can help to explain the association of Trauma with physical diseases and particularly CVD. It also suggests that PTSD is associated with specific neuroendocrine alterations. Moreover, increased renin Levels may also represent a risk factor for developing PTSD after traumatization.


Jan Terock (Author)
University of Greifswald

Our findings add to growing evidence for a crucial role of the renin-angiotensin-aldosterone-system in the pathophysiology of PTSD

Read Publication

The following have contributed to this page: Jan Terock

In partnership with: