Dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography

Somchai Amornyotin, Wichit Srikureja, Wiyada Chalayonnavin, Siriporn Kongphlay
  • Hepatobiliary & Pancreatic Diseases International, June 2011, Elsevier
  • DOI: 10.1016/s1499-3872(11)60052-0

Dose requirement and complications of diluted and undiluted propofol for deep sedation in ERCP

What is it about?

In general, the dose requirement and complications of propofol are lower when used in the diluted form than in the undiluted form. The aim of this study was to determine the dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography.

Why is it important?

All endoscopies were completed successfully. Mean propofol doses per body weight and per body weight per hour in groups D (diluted propofol) and U (undiluted propofol) were 3.0 mg/kg, 6.2 mg/kg per hour and 4.7 mg/kg, 8.0 mg/kg per hour, respectively. The mean dose of propofol, expressed as total dose, dose/kg or dose/kg per hour and the recovery time were not significantly different between the two groups. Sedation-related adverse events during and immediately after the procedure were higher in group U (undiluted propofol) (42.9%) than in group D (diluted propofol) (18.2%) (P=0.013).

Perspectives

Somchai Amornyotin
Department of Anesthesiology, Faculty of Medicine Siriraj Hospital, Mahidol University

Propofol requirement and recovery time in the diluted and undiluted propofol groups were comparable. However, the sedation-related hypotension was significantly lower in the diluted group than the undiluted group.

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http://dx.doi.org/10.1016/s1499-3872(11)60052-0

The following have contributed to this page: Somchai Amornyotin